O’Brien Publications


Bitzer M, Ju W, Jing X, Zavadil J. Quantitative analysis of miRNA expression in epithelial cells and tissues. Quantitative Analysis of miRNA Expression in Epithelial Cells and Tissues. Methods Mol Biol. 2012; 820:55-70.

Lim J, Menon V, Bitzer M, Miller LM, Madrid-Aliste C, Weiss LM, Fiser A, Angeletti RH. Frozen tissue can provide reproducible proteomic results of subcellular fractionation. Anal Biochem. 2011 Nov 1;418(1):78-84. Epub 2011 Jul 13. PMCID:PMC3164751

Razani B, Zhang XL, Bitzer M, von Gersdorff G, Bottinger EP, Lisanti MP. Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor. J Biol Chem. 2001 Mar 2;276(9):6727-38.

Siroky BJ, Bitzer M. The Growing Importance of mTORC1-S6K1 Signaling in Kidney. Am J Physiol Renal Physiol. 2009 Sep;297(3):F583-4. Epub 2009 Jul 1.

Susztak K, Bitzer M, Meyer TW, Hostetter TH. Animal Models of Kidney Disease. Commentary. Kidney Int. 2008 Mar;73(5):526-8.

von Gersdorff G, Susztak K, Rezvani F, Bitzer M, Liang D, Bottinger EP. Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor beta. J Biol Chem. 2000 Apr 14;275(15):11320-6.

Yaddanapudi S, Altintas MM, Kistler AD, Fernandez I, Möller CC, Wei C, Peev V, Flesche JB, Forst AL, Li J, Patrakka J, Xiao Z, Grahammer F, Schiffer M, Lohmüller T, Reinheckel T, Gu C, Huber TB, Ju W, Bitzer M, Rastaldi MP, Ruiz P, Tryggvason K, Shaw AS, Faul C, Sever S, Reiser J. CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. J Clin Invest. 2011 Oct 3;121(10):3965-80. PMCID: PMC3195478

Zhou L, McMahon C, Bhagat T, Alencar C, Yu Y, Fazzari M, Sohal D, Heuck C, Gundabolu K, Ng C, Mo Y, Shen W, Wickrema A, Kong G, Friedman E, Sokol L, Mantzaris G, Pellagatti A, Boultwood J, Platanias LC, Steidl U, Yan L, Yingling JM, Lahn MM, List A, Bitzer M, Verma A. Reduced SMAD7 Leads to Overactivation of TGF-beta Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-beta Receptor I Kinase. Cancer Res. 2011 Feb 1;71 (3):955-63. Epub 2010 Dec 28. PMCID: PMC3032816

Zhou L, Nguyen AN, Sohal D, Ma JY, Pahanish P, Gundabolu K, Hayman J, Chubak A, Mo Y, Bhagat T, Das B, Haghnazari E , Navas TA, Parmar S, Kambhampati S, Pellagati A, Braunchweig I, Zhang Y, Wickrema A, Boultwood J, Platanias L, Higgins LS, List AA, Bitzer M, Verma A. Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis, Blood. 2008 May 12;112 (8):3005-6. PMCID: PMC2569182


Hodgin JB, Nair V, Zhang H, Harris R, Nelson R, Weil E, Patel J, Brosius FC, 3rd, Kretzler M. Identification of cross-species shared transcriptional networks of diabetic nephropathy in human and mouse glomeruli. Diabetes. 2012 Nov 8. [Epub ahead of print]

Ju W and Brosius F. Understanding Kidney Disease: Toward the Integration of Regulatory Networks Across Species. Semin Nephrol 30(5): 512-519, 2010 PMCID: PMC2989742

Buller C L, Loberg RD, Fan M-H, Zhu Q, Park JL, Vesely E, Inoki K, Guan K, Brosius FC III. A GSK-3, TSC2, mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression, Am J Physiol Cell Physiol, 2008 Sep;295(3):C836-43. Epub 2008 Jul 23. PMCID: PMC2544442

Brosius FC III. New insights into the mechanisms of fibrosis and sclerosis in diabetic nephropathy. Rev Endocr Metab Disord. 2008;9:245-54.

Berthier CC, Zhang H, Schin ML, Henger A, Nelson RG, Yee B, Boucherot A, Carter-Su C, Argetsinger LS, Rastaldi MP, Brosius FC*, Kretzler, M. Enhanced Expression of JAK-STAT Pathway Members in Human Diabetic Nephropathy, Diabetes, 2009, Feb;58(2):469-77. (*corresponding author). PMCID: PMC2628622

Atkins KB, Irey B, Xiang N, Brosius FC 3rd. A rapid, PPAR-gamma-dependent effect of pioglitazone on the phosphorylation of MYPT. Am J Physiol Cell Physiol. 2009 May;296(5):C1151-61. Epub 2009 Mar 4. PMCID: PMC2681377

Zhao W, Thacker SG, Hodgin JB, Zhang H, Wang JH, Park JL, Randolph A, Somers EC, Pennathur S, Kretzler M, Brosius FC 3rd, Kaplan MJ. The peroxisome proliferator-activated receptor gamma agonist pioglitazone improves cardiometabolic risk and renal inflammation in murine lupus. J Immuno, 2009 Aug 15;183(4):2729-40. PMCID: PMC2765333

Vesely ED, Heilig CW, Brosius FC 3rd. GLUT1-induced cFLIP expression promotes proliferation and prevents apoptosis in vascular smooth muscle cells. Am J Physiol Cell Physiol, 2009 Sep, 297:C759-65. PMCID: PMC2740397

Brosius FC III, Khoury GC, Buller CL, Chen S. Abnormalities in Signaling Pathways in Diabetic Nephropathy. Expert Rev Endocrinol Metab, 2010 May;5(1):51-64 PMCID: PMC2834210

Zhang H, Schin M, Saha J, Burke K, Holzman LB, Filipiak W, Saunders T, Heilig C, Brosius FC 3rd. Podocyte Specific Overexpression of GLUT1 Surprisingly Reduces Mesangial Matrix Expansion in Diabetic Nephropathy in Mice. Am J Physiol Renal Physiol. 2010 Jul;299(1):F91-8. PMCID: PMC2904178

Brosius FC. Susceptible mice: identifying a diabetic nephropathy disease locus using a murine model. Kidney Int. 2010 Aug;78:431-2.

Ju W, Brosius FC 3rd. Understanding kidney disease: toward the integration of regulatory networks across species. Semin Nephrol. Sep 2010;30(5):512-9 PMCID: PMC2989742

Kumar PA, Brosius FC 3rd, Menon RK. The Glomerular Podocyte as a Target of Growth Hormone Action: Implications for the Pathogenesis of Diabetic Nephropathy. Curr Diabetes Rev. 2011 Jan 1;7(1):50-5.

Buller C, Heilig CW, Brosius FC 3rd. GLUT1 enhances mTOR activity independently of TSC2 and AMPK, Am J Physiol Renal Physiol. 2011 Sep; 301(3):F588-96. PMCID: PMC3174561

Brosius FC 3rd, Saran R. Do We Now Have a Prognostic Biomarker for Progressive Diabetic Nephropathy? J Am Soc Nephrol, 2012 Mar;23(3):376-7. Epub 2012 Feb 9.

Komorowski CV, Brosius FC 3rd, Pennathur S, Kretzler M. Perspectives on Systems Biology Applications in Diabetic Kidney Disease. J Cardiovasc Transl Res. 2012 Aug;5(4):491-508. Epub Jun 26. PMCID: PMC3422674

Hodgin JB. Nair V, Zhang H, Randolph A, Harris RC, Nelson RG, Weil EJ, Patel J, Brosius FC 3rd*, Kretzler M. Identification of cross-species shared transcriptional networks of diabetic nephropathy in human and mouse glomeruli. (*corresponding author),

Brosius FC 3rd, Alpers CW. New Targets for Treatment of Diabetic Nephropathy: What We Have Learned from Animal Models. Current Opinion in Nephrology and Hypertension, 2012. In press


Myers MG Jr, Burant CF. PPAR-γ action: it's all in your head. Nat Med. 2011 May;17(5):544-5.


Hur J, Sullivan KA, Pande M, Hong Y, Sima AA, Jagadish HV, Kretzler M, Feldman EL. The identification of gene expression profiles associated with progression of human diabetic neuropathy. Brain, 134 (Pt 11), 3222-3235, 2011. PMCID: PMC3212712

Pop-Busui R, Roberts L, Pennathur S, Kretzler M, Brosius FC, Feldman, EL. The Management of diabetic Neuropathy in CKD. Am J Kidney Dis, Am J Kidney Dis. 2010 Feb;55(2):365-85. Epub 2009 Dec 30.


Billecke SS, D'Alecy LG, Patel R, Whitesall SE, Jamerson KA, Perlman RL, Gadegbeku CA: Blood content of asymmetric dimethylarginine: new insights into its dyregulation in renal disease. Neph Dial Trans 24:489-496, 2009. PMCID: PMC2734175

Gadegbeku CA, Kreger Stillman P, Huffman MD, Jackson JS, Kusek JW, Jamerson KA: Factors associated with enrollment of African Americans into a clinical trial: results from the African American study of kidney disease and hypertension. Contemp Clin Trials 29:837-842, 2008. PMCID: PMC2668212

Appel LJ, Wright, Jr. JT, Greene T, Agodoa LY, Astor BC, Bakris GL, Cleveland WH, Charleston J, Contreras G, Faulkner ML, Gabbai FB, Gassman JJ, Hebert LA, Jamerson KA, Kopple JD, Kusek JW, Lash JP, Lea JP, Lewis J,B Lipkowitz MS, Massry SG, Miller ER, Norris K, Phillips RA, Pogue VA, Randall OS, Rostand SG, Smogorzewski MJ, Toto RD, Wang X for the AASK Collaborative Research Group. Intensive blood-pressure control in hypertensive chronic kidney disease. N Engl J Med 363:918-929, 2010.


Venkatareddy M, Cook L, Abuarquob K, Verma R and Garg P. Nephrin regulates lamellipodia formation by assembling a protein complex that includes ship2, filamin and lamellipodin. PLoS ONE 6(12): e28710.


Tanzer, M., Tran, C., Messer, K., Kroeker, A., Herreshoff, E., Wickman, L. Harkness, C., Song, PXK and Gipson, D. (2012). Inpatient healthcare utilization by children and adolescents with systematic lupus erythematosus and kidney involvement. Arthritis Care & Research (accepted).

Tran, C.L., Ehrmann, B.J. Messer, K.L., Herreshoffa, E., Kroekera, A., Wickman, L., Song, PXK, Kaspera, N. and Gipson, D.S. (2012). Recent trends in healthcare utilization among children and adolescents with hypertension in the United States. Hypertension (accepted).


Zhang, F., Zhao, Y., and Han, Z. (2012). Establishing an in vivo functional analysis system for renal gene discovery in Drosophila pericardial nephrocytes. Journal of the American Society of Nephrology (JASN) (Submitted)

Zhang, F., Zhao, Y., Chao, Y., Muir, K., and Han, Z. (2012). Renal proximal tubule receptors Cubilin and Amnionless mediate protein reabsorption in Drosophila nephrocytes. Journal of the American Society of Nephrology (JASN) (Submitted)


Billing H, Muller D, Ruf R, Lichtenberger A, Hildebrandt F, August C, Querfeld U, Haffner D. NPHS2 mutation associated with recurrence of proteinuria after transplantation. Pediatr Nephrol 19:561-564, 2004.

Chaib H, Hoskins BE, Ashraf S, Goyal M, Wiggins RC, Hildebrandt F. Identification of BRAF as a new interactor of PLC{epsilon}1, the protein mutated in nephrotic syndrome type 3. Am J Physiol Renal Physiol, 2007 Oct [Epub ahead of print].

Gbadegesin R, Hinkes B, Vlangos C, Mucha B, Liu J, Hopcian J, and Hildebrandt F. Mutational analysis of NPHS2 and WT1 in frequently relapsing and steroid-dependent nephrotic syndrome. Pediatr Nephrol 22:509-13, 2007.

Hasselbacher K, Wiggins RC, Matejas V, Hinkes BG, Mucha B, Hoskins BE, Ozaltin F, Nurnberg G, Becker C, Hangan D, Pohl M, Kuwertz-Broking E, Griebel M, Schumacher V, Royer-Pokora B, Bakkaloglu A, Nurnberg P, Zenker M, Hildebrandt F. Recessive missense mutations in LAMB2 expand the clinical spectrum of LAMB2-associated disorders. Kidney Int 70:1008-12, 2006 (editorial p. 980-2).

He N, Zahirieh A, Mei Y, Lee B, Senthilnathan S, Wong B, Mucha B, Hildebrandt F, Cole DE, Cattran D, Pei Y. Recessive NPHS2 (Podocin) mutations are rare in adult-onset idiopathic focal segmental glomerulosclerosis. Clin J Am Soc Nephrol 2:31-7, 2007.

Hinkes B, Vlangos C, Heeringa S, Mucha B, Gbadegesin R, Liu J, Hasselbacher K, Ozaltin F, Hildebrandt F and Members of the APN Study Group*. Specific podocin (NPHS2) mutations correlate with age of onset in steroid resistant nephrotic syndrome. J Am Soc Nephrol. 2008 Feb;19(2):365-71. Epub 2008 Jan 23. PMCID:PMC2396749

Hinkes B1, Wiggins RC1, Gbadegesin R, Vlangos CN, Seelow D, Nurnberg G, Garg P, Verma R, Chaib H, Hoskins BE, Ashraf S, Becker C, Hennies HC, Goyal M, Wharram BL, Schachter AD, Mudumana S, Drummond I, Kerjaschki D, Waldherr R, Dietrich A, Ozaltin F, Bakkaloglu A, Cleper R, Basel-Vanagaite L, Pohl M, Griebel M, Tsygin AN, Soylu A, Muller D, Sorli CS, Bunney TD, Katan M, Liu J, Attanasio M, O'toole JF, Hasselbacher K, Mucha B, Otto EA, Airik R, Kispert A, Kelley GG, Smrcka AV, Gudermann T, Holzman LB, Nurnberg P, Hildebrandt F. Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nature Genet 38:1397-405, 2006 (1equal contribution) (editorial p. 1360-1).

Hinkes BG, Mucha B, Vlangos CN, Gbadegesin R, Liu J, Hasselbacher K, Hangan D, Ozaltin F, Zenker M, and Hildebrandt F. Nephrotic Syndrome in the First Year of Life: Two Thirds of Cases Are Caused by Mutations in 4 Genes (NPHS1, NPHS2, WT1, and LAMB2). Pediatrics 199:e907-919, 2007 (editorial in Nature Clin Pract Nephrol 9:472-3, 2007).

Mucha B, Ozaltin F, Hinkes B, Hasselbacher K, Ruf R, Schultheiss M, Hangan D, Hoskins B, Schulze-Everding A, Bogdanovic R, Seeman T, Hildebrandt F, and Members of the APN Study Group. Mutations in the Wilms' Tumor 1 Gene Cause Isolated Steroid Resistant Nephrotic Syndrome and Occur in Exons 8 and 9. Pediatr Res 59:325-31, 2006 (editorial p. 165-6).

Ruf RG, Fuchshuber A, Karle SM, Lemainque A, Huck K, Wienker T, Otto E, Hildebrandt F. Identification of the first gene locus (SSNS1) for steroid-sensitive nephrotic syndrome on chromosome 2p. J Am Soc Nephrol 14:1897-1900, 2003.

Ruf RG, Lichtenberger A, Karle SM, Haas JP, Anacleto FE, Schultheiss M, Zalewski I, Imm A, Ruf EM, Mucha B, Bagga A, Neuhaus T, Fuchshuber A, Bakkaloglu A, Hildebrandt F & Members of the APN Study Group. Patients with mutations in NPHS2 (podocin) do not respond to standard steroid treatment of nephrotic syndrome. J Am Soc Nephrol 15:722-32, 2004 (with editorial).

Ruf RG, Schultheiss M, Lichtenberger A, Karle SM, Mucha B, Everding AS, Neuhaus T, Patzer, Plank C, Haas JP, Imm A, Fuchshuber A, Bakkaloglu A, Hildebrandt F, APN Study Group. Prevalence of Mutation in WT1 in a Large Cohort of Patients with Steroid-Resistant and Steroid-Sensitive Nephrotic Syndrome. Kidney Int 66:564-5670, 2004.

Schultheiss M, Ruf RG, Mucha BE, Wiggins R, Fuchshuber A, Lichtenberger A, Hildebrandt F. No evidence for genotype/phenotype correlation in NPHS1 and NPHS2 mutations. Pediatr Nephrol 19:1340-1348, 2005.


Inoki K, Mori H, Wang J, Suzuki T, Hong S, Yoshida S, Blattner SM, Ikenoue T, Ruegg MA, Hall MN, Kwiatkowski DJ, Rastaldi MP, Huber TB, Kretzler M, Holzman LB, Wiggins RC, Guan KL. mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. J Clin Invest. 2011 Jun;121(6):2181-96. 888888: 21606597, PMCID: PMC3104745


Bottinger E, Ju W, and Zavadil J.  Application of Microarrays in Renal Biology and Medicine.  Exp. Nephrol 10: 93-101, 2002.

Ju W, Ogawa A, Heyer J, Nierhof D, Yu L, Schafritz D, Kucherlapati R, and Bottinger E. Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation. Mol. Cell. Biol. 26 (2), 654-667, 2006.

Bottinger E & Ju W. Gene expression signatures of Tgf-beta/ Smad-induced responses, Chapter 17 of Smad Signal Transduction • Smads in Proliferation, Differentiation and Disease. Dijke, P.t., Heldin, C.-H. (Eds.), Vol. 5, ISBN 978-1-4020-4542-4, 2006.

Krick S, Shi S, Ju W, Mundel P, and Bottinger E. Mpv17l Protects against Mitochondrial Oxidative Stress and Apoptosis by Activation of Omi/HtrA2 protease. Proc. Natl. Acad. Sci. U.S.A, 105(37), 14106-14111, 2008.

Hoot K, Lighthall J, Lu S, Han G, Li A, Ju W, Kulesz-Martin M, Bottinger E, Wang XJ. Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression. J. Clin. Invest. 118(8) 2722-2732, 2008.

Lal G, Zhang N, van der Touw W, Ding Y, Ju W, Bottinger E, Reid P, Levy D and Bromberg J. Epigenetic regulation of Foxp3 expression and regulatory T cells by DNA methyltransferase.  J. Immunol. 182(1):259-73, 2009.

Ju W, Eichinger F, Bitzer M, Oh J, McWeeney S, Berthier C,  Shedden K,  Cohen C,  Henger A, Krick S, Kopp J, Stoeckert C, Dikman S, Schröppel B, Thomas D, Schlondorff D, Kretzler M and Bottinger E. Renal Gene and Protein Expression Signatures for Prediction of Kidney Disease Progression. Am. J. Pathol. 174 (6): 2073-2085, 2009.

Xavier S, Niranjan T, Krick S, Zhang T, Ju W, Shaw A, Schiffer M, and Bottinger E. TGFBRI Independently Activates Smad- and CD2APDependent Pathways in Podocytes. J. Am. Soc. Nephrol. 20 (10):2127-2137, 2009.

Ju W and Brosius F. Understanding Kidney Disease: Toward the Integration of Regulatory Networks Across Species. Semin Nephrol 30(5): 512-519, 2010

Meng X, Huang X, Chung A , Wei Q, Shao X, Igarashi P, Ju W, Bottinger E, and Lan HY. Smad2 protects against TGF-β/Smad3-mediated renal fibrosis in vivo and in vitro. J. Am. Soc. Nephrol. 21(9):1477-87, 2010.

Kohn E, Du Z, Sato M, Van Schyndle C, Welsh M, Yang Y, Stuelten C, Tang B, Ju W, Bottinger E, and Wakefield L. A novel approach for the generation of genetically modified mammary epithelial cell cultures yields new insights into TGF-β signaling in the mammary gland. Breast Cancer Research,  12:R83, 2010

Yaddanapudi S,  Altintas M, Kistler A, Fernandez I, Moeller C,  Wei C,  Peev V, Flesche J,  Forst A, Li J, Patrakka J, Xiao Z,  Grahammer F,  Schiffer M,  Lohmuller T, Reinheckel T, Gu C,  Huber T,  Ju W, Bitzer M,  Rastaldi M,  Ruiz P,  Tryggvason K,  Shaw A, Faul C,  Sever S, and Reiser J. CD2AP in kidney podocytes controls a proteolytic program that regulates cytoskeleton and cellular survival. J Clin Invest 121(10): 3965-3980, 2011

Vivekanandan-Giri A,  Slocum JL, Buller CL, Basrur V, Ju W, Pop-Busui R, Lubman, DM, Kretzler M, and Pennathur S. Urine Glycoprotein Profile Reveals Novel Markers for Chronic Kidney Disease. International Journal of Proteomics volume , Article ID 214715, 2011

Bitzer M, Ju W, Jing X, and Zavadil J. Quantitative Analysis of miRNA Expression in Epithelial Cells and Tissues. Cytokine Protocols, Chapter 4, Methods Mol Biol. 2012;820:55-70
Ju W*, Smith S, and Kretzler M. Genomic Biomarkers for Chronic Kidney Disease. Trans Res., 159(4):290-302, 2012. * Corresponding author.

Bhagat T D, Zhou L, Sokol L, Caceres G,  Gundabolu K, Gordon S, Mantzaris I, Gligich O, Yu Y,  Bhattacharyya S, Jing X, Polineni R, Tamari R, Bhatia K, Pellagatti A, Boultwood J, Kambhampati S, Steidl U, Stein C, Ju W, Liu G, Kenny P, List A, Bitzer M, and Verma A. miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling. Blood, 121(15): 2875-2881, 2013

Wanic K, Krolewski B, Ju W, Placha G, Niewczas M, Walker W, Warram J, Kretzler M and Krolewski A. Transcriptome analysis of Proximal Tubular Cells (HK-2) exposed to Urines of Type 1 Diabetes Patients at Risk of Early Progressive Renal Function Decline. PLOS ONE 8 (3): 1-10, 2013

Xiw W, Li Z, Ju W, Xie Q, Han J, Liu T, Bottinger E, Chai Y, Jose P, and Chen S. Smad2 and MRTFB cooperatively regulate vascular smooth muscle differentiation from neural crest cells. Circ. Res. Accepted. 2013  

Ju W, Greene C, Eichinger F, Nair V, Hodgin J, Bitzer M, Lee Y, Zhu Q, Kehata M, Li M, Rastaldi MP, Cohen C, Troyanskaya O, and Kretzler M. In silico nano-dissection: defining cell type specificity at transcriptional level in human disease. In revision. 2013


Denny MF, Yalavarthi S, Zhao W, Thacker S, Anderson M, Sandy A, McCune WJ, and Kaplan MJ. A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I Interferons. J Immunol 2010; 184:3284-97. PMCID:PMC2929645.

Somers EC, Zhao W, Lewis, EE, Wang L, Wing JJ, Baskaram S, Kazerooni E, McCune WJ, Kaplan MJ. Type I interferons are associated with subclinical markers of cardiovascular disease in a cohort of systemic lupus erythematosus patients. PLoS ONE 2012; 7(5):e37000. PMCID: PMC3351452.

Thacker S, Zhao W, Smith C, Luo W, Wang H, Vivekanandan-Giri, A, Rabquer B, Koch AE, Pennathur S, Davidson A, Eitzman D, Kaplan MJ. Type I interferons modulate endothelial function, repair, thrombosis and plaque severity in murine models of lupus and atherosclerosis. Arthritis Rheum 2012 Sep;64(9):2975-85. doi: 10.1002/art.34504. PMCID: PMC3411886

Villanueva E, Yalavarthi S, Berthier C, Hodgin J, Khandpur R, Lin A, Rubin C, Zhao W, Olsen SH, Klinker M, Shealy D, Denny MF, Plumas J, Chaperot L, Kretzler M, Bruce AT and Kaplan MJ. Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus. J Immunology. 2011 Jul 1;187(1):538-52. PMCID: PMC3119769.


Boger, CA, Chen MH, Tin A, Olden M, Kottgen A, Deboer IH, Fuchsberger C, O'Seaghdha CM, Pattaro C, Teumer A, et al. (2011) CUBN is a gene locus for albuminuria. J Am Soc Nephrol 22(3):555-570. 888888: 21355061; PMCID: PMC3060449

Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, O'Connell JR, et al. (2010) New loci associated with kidney function and chronic kidney disease. Nat Genet 42(5):376-384. 888888: 20383146; PMCID: PMC2997674

Liu C-T, Garnaas MK, Tin A, Kottgen A, Franceschini N, Peralta CA, Boer IH, Lu X, Atkinson E, Ding J, Nalls M, Shriner D, Coresh J, Kutlar A, Bibbins-Domingo K, Siscovick D, Akylbekova E, Wyatt S, Astor B, Mychaleckjy J, Li M, Reilly MP, Townsend R, Adeyemo A, Zonderman AB, de Andrade M, Turner ST, Mosley TH, Harris TB, the CKDGen Consortium, Rotimi CN, Liu Y, Kardia SLR, Evans MK, Shlipak MG, Kramer H, Flessner MF, Dreisbach AW, Goessling W, Cupples LA, Kao WL, Fox CS. (2011) Genetic association for renal traits among participants of African ancestry reveals new loci for renal function. PLoS Genetics. 7(9): e1002264. 888888: 21931561. PMCID: PMC3169523

Pattaro C, Köttgen A, Teumer A, Garnaas M, Böger CA, Fuchsberger C, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, et al. Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet. 2012 8(3):e1002584. PubMed 888888: 22479191; PubMed Central PMCID: PMC3315455.

Turner ST, Rule AD, Schwartz GL, Kullo IJ, Mosley TH, Jack CR, Kardia SLR, Boerwinkle E, Bailey KR (2011) Risk factor profile for chronic kidney disease is similar to risk factor profile for small artery disease. J Hypertens 29(9):1786-1801. 888888: 21720267, PMC – In Process


Appel D, *Kershaw DB, Smeets B, Yuan G, Fuss A, Frye B, Elger M, Kriz W, Floege J, Moeller MJ. Recruitment of Podocytes from Glomerular Parietal Epithelial Cells J Am Soc Nephrol. 2009 Feb;20(2):333-43.* PMCID: PMC2637040


Berthier CC, Bethunaickan R, Gonzalez-Rivera T, Nair V, Ramanujam M, Zhang W, Bottinger EP, Segerer S, Lindenmeyer M, Cohen CD, Davidson A, Kretzler M. Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis. J Immunol. 2012 Jul 15;189(2):988-1001. Epub 2012 Jun 20. PMCID: PMC3392438

Berthier CC, Kretzler M, Davidson D. From the large scale expression analysis of lupus nephritis to targeted molecular medicine. Journal of Data Mining in Genomics & Proteomics, in press, 2012. PMCID: pending

Berthier CC, Zhang H, Schin ML, Henger A, Nelson RG, Yee B, Boucherot A, Neusser M, Cohen CD, Carter-Su C, Argetsinger LS, Rastaldi, MP, Brosius FC, Kretzler M. Enhanced Expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy. Diabetes. 2009 Feb;58(2):469-77. PMCID: PMC2628622

Bethunaickan R, Berthier CC, Ramanujam M, Sahu R, Zhang W, Sun Y, Bottinger EP, Ivashkiv L, Kretzler M, Davidson A. A unique hybrid renal mononuclear phagocyte activation phenotype in murine systemic lupus erythematosus nephritis. J Immunol. 2011 Apr 15;186(8):4994-5003. PMCID: PMC3159403

Reich HN, Tritchler D, Cattran DC, Herzenberg AM, Eichinger F, Boucherot A, Henger A, Berthier CC, Nair V, Cohen CD, Scholey JW, Kretzler M. A molecular signature of proteinura in glomerulonephritis. PLoS One. 2010 Oct; 5(10):e13451. 888888: 20976140, PMCID: PMC2956647

Hodgin JD, Borczuk AC, Nasr SH, Markowitz GS, Nair V, Martini S, Eichinger F, Vining C, Berthier C, Kretzler M, D'Agati VD. A molecular profile of focal segmental glomerulosclerosis from Fromalin-fixed, paraffin-embedded tissue. Am J Pathol. 2010 Oct; 177(4):1674-86. PMCID: PMC2947265

Ju W*, Smith S, and Kretzler M. Genomic Biomarkers for Chronic Kidney Disease. Trans Res., 159(4): 290-302, 2012. * Corresponding author. PMCID: PMC3329158

Ju W, Eichinger F, Bitzer M, Oh J, McWeeney S, Berthier CC, Shedden K, Cohen CD, Henger A, Krick S, Kopp JB, Stoeckert C, Dikman S, Schroeppel B, Kretzler M and Bottinger EP. Renal Gene and Protein Expression Signatures for Prediction of Kidney Disease Progression. Am J Pathol. 2009 Jun;174 (6):2073-85. PMCID: PMC2684173

Kahlenberg JM, Thacker SG, Berthier CC, Cohen CD, Kretzler M, Kaplan MJ. Inflammasome activation of IL-18 results in endothelial progenitor cell cysfunction in systemic lupus erythematosus. J Immunol. 2011 Dec 1; 187(11):6143-56. PMCID: PMC3221936

Mirel B, Eichinger F, Keller B, Kretzler M. A cognitive task analysis of a visual analytic workflow: Exploring molecular interaction networks in systems biology. Journal of Biomedical Discovery and Collaboration. 2011 Mar 21;6:1-33. PMCID: PMC3090070.

Mirel B, Eichinger F, Nair V, Kretzler M. Integrating automated workflows, human intelligence and collaboration. Summit on Translat. Bioinforma. Mar 1;2009:79-83. PMCID: PMC3041562

Thacker SG, Berthier C, Mattinzoli D, Rastaldi MP, Kretzler M, Kaplan MJ. The detrimental effects of interferon-α on vasculogenesis in lupis are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction. J Immunol. 2010 Oct; 185(7):4457-4469. PMCID: PMC2978924

Zhao W, Thacker SG, Hodgin JB, Zhang H, Wang JH, Park JL, Randolph A, Somers EC, Pennathur S, Kretzler M, Brosius FC 3rd, Kaplan MJ. The peroxisome proliferator-activated receptor gamma agonist pioglitazone improves cardiometabolomic risk and renal inflammation in murine lupus. J Immunol 2009 Aug 15; 183(4):2729-40. PMCID: PMC2765333

Vasko R, Koziolek MJ, Ikehata M, Rastaldi MP, Jung K, Schmid H, Kretzler M, Muller GA, Strutz F. Role of basic fibroblast growth factor (FGF-2) in diabetic nephropathy and mechanisms of its induction by hyperglycemia in human renal fibroblasts. Am J Physiol Renal Physiol. 2009 Jun;296(6):F1452-63.

Sen K, Lindenmeyer M, Gaspert A, Eichinger F, Neusser M, Kretzler M, Segerer S, Cohen C. Periostin is induced in glomerular injury and de novo expressed in interstitial renal fibrosis. Am J Path. 2011 Oct; 179(4):1756-67. PMCID: PMC3181392.

Sandholm N, Kretzler M, Maxwell AP: New susceptibility loci associated with kidney disease in type 1 diabetes. PLoS Genet. 2012 Sep;8(9):e1002921. doi: 10.1371/journal.pgen.1002921. Epub 2012 Sep 20. PMCID: PMC3447939

Sanchez-Nino MD, Sanz AB, Lorz C, Gnirke A, Rastaldi MP, Nair V, Egido J, Ruiz-Ortega M, Kretzler M*, Ortiz A*. BASP1 promotes apoptosis in diabetic nephropathy. J Am Soc Nephrol. 2010 Apr; 21(4):610-21. PMCID: PMC2844309

Sanchez-Nino MD, Sanz AB, Ihalmo P, Lassila M, Holthofer H, Mezzano S, Aros C, Groop PH, Saleem MA, Mathieson PW, Langham R, Kretzler M, Nair V, Lemley K, Nelson RG, Mervaala E, Mattinzoli D, Rastaldi MP, Ruiz-Ortega M, Martin-Ventura JL, Egido J, Ortiz A. The MIF receptor CD74 in diabetic podocyte injury. J Am Soc Nephrol. 2009 Feb;20(2):353-62. PMCID: PMC2637042

Raffetseder U, Rauen T, Djudjaj S, Kretzler M, En-Nia A, Tacke F, Zimmerman HW, Nelson PJ, Frye BC, Floege J, Stefanidis I, Weber C, Mertens PR. Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein-1. Kidney Int. 2009 Jan;75(2):185-96.

Neusser M, Lindenmeyer MT, Moll AG, Segerer S, Edenhofer I, Sen K, Kretzler M, Groene HJ, Schlondorff D, Cohen CD. Human nephrosclerosis triggers a hypoxia-related glomerulopathy. Am J Path. 2010 Feb; 176 (2):594-607. PMCID: PMC2808068

Moll AG, Lindenmeyer MT, Kretzler M, Nelson PJ, Zimmer R, Cohen CD. Transcript-Specific Expression Profiles derived from Sequence-Based Analysis of Standard Microarrays. PloS One. 2009;4(3):e4702. PMCID: PMC2650090.

Mendoza J, Isakova T, Ricardo A, Huiliang X, Navaneethan S, Anderson A, Bazzano L, Xie D, Kretzler M, Nessel L, Hamm L, Negrea L, Leonard M, Raj D, Wolf M. Fibroblast growth factor 23 and inflammation in chronic kidney disease. CJASN. 2012 May 17. PMCID: PMC3386678

Martini S, Eichinger F, Nair V, Kretzler M. Defining human diabetic nephropathy on the molecular level: Integration of transcriptomic profiles with biological knowledge. Rev Endocr Metab Disord. 2008 Dec;9(4):267-74. 888888: 18704688, PMCID: PMC2597685.

Luan F, Trillsch F, Henger A, Eichinger F, Norman S, Appelman H, Kretzler M. A Pilot Study of Gene Expression-Based Categorization of Pancreas Transplant Biopsies. Transplantation. 2009 Jan 27;87(2):222-6.

Lindenmeyer MT, Eichinger F, Sen K, Anders HJ, Edenhofer I, Mattinzoli D, Kretzler M, Rastaldi MP, Cohen CD. Systematic analysis of a novel human renal glomerulus-enriched gene expression dataset. PLoS One. 2010 Jul; 5(7):e11545. PMCID: PMC2902524

Lau GJ, Godin N, Maachi H, Lo CS, Wu SJ, Zhu JX, Brezniceanu ML, Chenier I, Fragasso-Marquis J, Lattouf JB, Ethier J, Filep JG, Ingelfinger JR, Nair V, Kretzler M, Cohen CD, Zhang SL, Chan J. Bcl-2-Modifying Factor Induces Renal Proximal Tubular Cell Apoptosis in Diabetic Mice. Diabetes. 2012 Feb;61(2):474-84. PMCID: PMC3266424

Lau GJ, Godin N, Maachi H, Lo CS, Wu SJ, Zhu JX, Brezniceanu ML, Chenier I, Fragasso-Marquis J, Lattouf JB, Ethier J, Filep JG, Ingelfinger JR, Nair V, Kretzler M, Cohen CD, Zhang SL, Chan J. Bcl-2-Modifying Factor Induces Renal Proximal Tubular Cell Apoptosis in Diabetic Mice. Diabetes. 2012 Feb;61(2):474-84. PMCID: PMC3266424

Kretzler M, Cohen CD. Integrative biology of renal disease: toward a holistic understanding of the kidney's function and failure. Semin Nephrol. 2010 Sep; 30(5):439-42. PMCID: PMC2990983

Keller BJ, Martini S, Sedor Jr, Kretzler M. A Systems View of Genetics in Chronic Kidney Disease. Kidney Int. 2012 Jan;81(1):14-21. 888888: 22112128

Keller BJ, Eichinger F, Kretzler M. Formal concept analysis of disease similarity. AMIA Summits Transl Sci Proc. 2012;2012:42-51. Epub 2012 Mar 19. PMCID: PMC3392047

Keller B, Martini M, Sedor J, Kretzler M. Linking variants from genome wide association analysis to function via transcriptional network analysis. Sem Nephrol. 2010 Mar; 30(2):177-84. PMCID: PMC2847590

Ju W, Smith S, Kretzler M. Genomic Biomarkers for Chronic Kidney Disease. Transl Res. 2012 Apr;159(4):290-302. PMCID: PMC3329158

Hodgin JB, Nair V, Zhang H, Randolph A, Harris RC, Nelson RG, Weil EJ, Patel JM, Brosius FC, Kretzler M: Identification of cross-species shared transcriptional networks of diabetic nephropathy in human and mouse glomeruli. Diabetes 2012 Nov 8. [Epub ahead of print].

Gross O, Girgert R, Beirowki B, Kretzler M, Kang HG, Kruegel J, Miosge N, Busse AC, Segerer S, Vogel WF, Müller GA, Weber M. Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease. Matrix Biology. 2010 Jun; 29(5):346-56.

Gong P, Canaan A, Wang B, Leventhal J, Snyder A, Nair V, Cohen CD, Kretzler M, D'Agati V, Weissman S, Ross JM. Novel Role for the ubiquitin-like protein FAT10 in NF-kB activation. J Am Soc Nephrol, 2010 Feb;21(2):316-26. PMCID: PMC2834541

Godel M, Hartleben B, Herbach N, Lu S, Debreczeni-Mor A, Liu S, Lindenmeyer MT, Rastaldi MP, Hartleben G, Wiech T, Fornoni A, Nelson RG, Kretzler M, Wanke R, Pavenstadt H, Kerjaschki D, Cohen CD, Hall MN, Ruegg MA, Inoki K, Walz G, and Huber TB. Role of mTOR podocyte function and diabetic nephropathy in humans and mice. J Clin Invest. 2011 Jun;121(6):2197-209. PMCID: PMC3104746

Endlich N, Schordan E, Cohen CD, Kretzler M, Lewko B, Welsch T, Kriz W, Otey CA, Endlich K; European Renal cDNA Bank Consortium. Palladin is a dynamic actin-associated protein in podocytes. Kidney Int. 2009 Jan;75(2):214-26.

El-Meanawy A, Schelling JR, Lyengar SK, Hayden P, Barathan S, Goddard K, Pozuelo F, Elashi E, Nair V, Kretzler M, Sedor JR. Identification of nephropathy candidate genes by comparing sclerosis-prone and sclerosis-resistant mouse strain kidney transcriptomes. BMC Nephrol. 2012 Jul 19;13(1):61.

Chuang PY, Dai Y, Liu R, He H, Kretzler M, Jim B, Cohen CD, He JC. Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus. PLoS One. 2011;6(8):e23566. PMCID: PMC3157434

Brosius FC 3rd, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB, Harris RC, Kakoki M, Kretzler M, Leiter EH, Levi M, McIndoe RA, Sharma K, Smithies O, Susztak K, Takahashi N, Takahashi T; for the Animal Models of Diabetic Complications Consortium. Mouse models of Diabetic Nephropathy. J Am Soc Nephrol. 2009 Dec; 20(12):2503-12.

Bramlage CP, Tampe B, Koziolek M, Maatouk I, Bevanda J, Bramlage P, Ahrens K, Lange K, Schmid H, Cohen CD, Kretzler M, Muller GA. Bone morphogenetic protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis. BMC Nephrol. 2010 Nov 16;11:31. PMCID: PMC3002344

Bramlage CP, Muller GA, Tampe B, Bevanda J, Maatouk I, Koziolek M, Lange K, Ahrens, K, Schmid H, Cohen CD, Bramlage P, Kretzler M, Strutz F. The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. J Nephrol. 2011 Sep-Oct;24(5):647-55.

Bhavnani SK, Ganesan AK, Hall T, Maslowski E, Eichinger F, Martini S, Saxman P, Bellala G, Kretzler M. Discovering hidden relationships between renal diseases and regulated genes through 3D network visualizations. BMC Research Notes. 2010 Nov; 3:296. PMCID: PMC3001742.

Bhavnani SK, Eichinger F, Martini S, Saxman, Jagadish HV, Kretzler M. Network Analysis of Genes Regulated in Renal Diseases: Implications for a Molecular-Based Classificatiion. BMC Bioinformatics. 2009 Sep 17;10 Suppl 9:S3. PMCID: PMC2745690

Berthier CC*, Bethunaickan R*, Gonzalez-Rivera T*, Nair V, Ramanujam M, Zhang W, Bottinger EP, Segerer S, Cohen CD, Davidson A, Kretzler M. Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis. J Immunol. 2012 Jul 15;189(2):988-1001. Epub 2012 Jun 20. PMCID: PMC3392438

Athey BD, Cavacoli JD, Jagadish HV, Omenn GS, Mirel B, Kretzler M, Burant C, Isokpehi RD, Delisi C; the NCIBI faculty, trainees, and staff. The NIH National Center for Integrative Biomedical Informatics (NCIBI). J am Med Inform Assoc. 2012 Mar-Apr;19(2):166-70. PMCID: PMC3277628

Boucher I, Yu W, Beaudry S, Negoro H, Tran M, Pollak MR, Henderson JM, Denker BM. Gα12 activation in podocytes leads to cumulative changes in glomerular collagen expression, proteinuria and glomerulosclerosis. Lab Invest. 2012 May;92(5):662-75. Epub 2012 Jan 16. PMCID: PMC3338890

Brennan EP, Morine MJ, Walsh DW, Roxburgh SA, Lindenmeyer MT, Brazil DP, Gaora PÓ, Roche HM, Sadlier DM, Cohen CD; GENIE Consortium, Godson C, Martin F. Next-generation sequencing identifies TGF-β1-associated gene expression profiles in renal epithelial cells reiterated in human diabetic nephropathy. Biochim Biophys Acta. 2012 Apr;1822(4):589-99. Epub 2012 Jan 14. PMCID: PMC3351834

Conway BR, Rennie J, Bailey MA, Dunbar DR, Manning JR, Bellamy CO, Hughes J, Mullins JJ. Hyperglycemia and renin-dependent hypertension synergize to model diabetic nephropathy. J Am Soc Nephrol. 2012 Mar;23(3):405-11. Epub 2011 Dec 22. PMCID: PMC3294297

Fugmann T, Borgia B, Révész C, Godó M, Forsblom C, Hamar P, Holthöfer H, Neri D, Roesli C. Proteomic identification of accessible proteins in a rat model of diabetic nephropathy reveals vanin-1 as a marker of kidney damage. Running headline: Biomarker of diabetic nephropathy Fugmann et al.Biomarker of diabetic nephropathy, Suppl. Methods Source: Supplementary material, Nature. Supplementary Methods1 Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland2 Institute of Pathophysiology, Semmelweis University, 1089 Budapest, Hungary3 Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, 00014 Helsinki, Finland4 Department of Medicine, Division of Nephrology, Helsinki University Hospital, 00014 Helsinki, Finland5 The Haartman Institute, University of Helsinki, 00014 Helsinki, Finland

Mühlberger I, Mönks K, Fechete R, Mayer G, Oberbauer R, Mayer B, Perco P. Molecular pathways and crosstalk characterizing the cardiorenal syndrome. OMICS. 2012 Mar;16(3):105-12.

Klein J, Jupp S, Moulos P, Fernandez M, Buffin-Meyer B, Casemayou A, Chaaya R, Charonis A, Bascands JL, Stevens R, Schanstra JP. The KUPKB: a novel Web application to access multiomics data on kidney disease FASEB J. 2012 May;26(5):2145-53. Epub 2012 Feb 17.

Arno Lukas1, and Bernd Mayer 1,2,*. Data Annotation and Relations Modeling for Integrated Omics in Clinical Research. The IIOAB Journal, Vol. 1; Issue 2; 2010

Neusser MA, Lindenmeyer MT, Moll AG, Segerer S, Edenhofer I, Sen K, Stiehl DP, Kretzler M, Gröne HJ, Schlöndorff D, Cohen CD. Human nephrosclerosis triggers a hypoxia-related glomerulopathy. Am J Pathol. 2010 Feb;176(2):594-607. Epub 2009 Dec 17. PMCID: PMC2808068

O'Donovan HC, Hickey F, Brazil DP, Kavanagh DH, Oliver N, Martin F, Godson C, Crean J. Connective tissue growth factor antagonizes transforming growth factor-b1/Smad signalling in renal mesangial cells. Biochem J. 2012 Jan 1;441(1):499-510.

Perco P, Oberbauer R. Integrative Analysis of -Omics Data and Histologic Scoring in Renal Disease and Transplantation: Renal Histogenomics. PMCID: PMC3359618

Rooney B, O'Donovan H, Gaffney A, Browne M, Faherty N, Curran SP, Sadlier D, Godson C, Brazil DP, Crean J. CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: Implications for the pathogenesis of diabetic nephropathy. FEBS Lett. 2011 Feb 4;585(3):531-8. Epub 2011 Jan 14.

Sanchez-Niño MD, Benito-Martin A, Ortiz A. New paradigms in cell death in human diabetic nephropathy. Kidney Int. 2010 Oct;78(8):737-44. Epub 2010 Aug 11.

Bielesz B, Sirin Y, Si H, Niranjan T, Gruenwald A, Ahn S, Kato H, Pullman J, Gessler M, Haase VH, Susztak K. Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest. 2010 Nov;120(11):4040-54. Epub 2010 Oct 18. PMCID: PMC2964979

Brian D Athey1, James D Cavalcoli1, H V Jagadish2, Gilbert S Omenn1, Barbara Mirel3, Matthias Kretzler4, Charles Burant5, Raphael D Isokpehi6, Charles DeLisi7. Brief communication: The NIH National Center for Integrative Biomedical Informatics (NCIBI). J Am Med Inform Assoc 2012;19:2 166-170 Published Online First: 19 November 2011

Hickey FB, Corcoran JB, Docherty NG, Griffin B, Bhreathnach U, Furlong F, Martin F, Godson C, Murphy M. IHG-1 Promotes Mitochondrial Biogenesis by Stabilizing PGC-1α. J Am Soc Nephrol. 2011 Aug;22(8):1475-85. Epub 2011 Jul 22. PMCID: PMC3148702

Fechete, R., Heinzel, A., Perco, P., Mönks, K., Söllner, J., Stelzer, G., Eder, S., Lancet, D., Oberbauer,R., Mayer, G., and Mayer, B. (2011), Mapping of molecular pathways, biomarkers, and drug targets for diabetic nephropathy. Prot. Clin. Appl., 5: 354–366. doi: 10.1002/prca.201000136


Norman, SP, Song, PXK, Hu, Y and Ojo, AO (2011). Transition from donor candidates to live donors: The impact of race and undiagnosed medical disease states. Clinical Transplantation 25, 136-145.


Patel SR, Bhumbra S, Paknikar RS, Dressler GR. Epigentic mechanisms of Groucho//Grg/TLE mediated transcriptional repression. Molecular Cell. 27;45(2):185-95, 2012. PMCID: PMC3268830


Sparks MA, Parsons KK, Stegbauer J, Gurley SB, Vivekanandan-Giri A, Fortner CN, Snouwaert J, Raasch EW, Griffiths RC, Haystead TA, Le TH, Pennathur S, Koller B, Coffman TM. Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension. Hypertension. 2011 Mar;57(3):577-85. PMCID: PMC3077960.

Vivekanandan-Giri A, Slocum JL, Buller CL, Basrur V, Ju W, Pop-Busui R, Lubman DM, Kretzler M, Pennathur S. Urine glycoprotein profile reveals novel markers for chronic kidney disease. Int J Proteomics. 2011;2011:214715. Epub 2011 Oct 10. PMCID: PMC3196258.

Vivekanandan-Giri A, Wang JH, Byun J, Pennathur S. Mass spectrometric quantification of amino acid oxidation products identifies oxidative mechanisms of diabetic end-organ damage. Rev Endocr Metab Disord. 2008 Dec;9(4):275-87. PMCID: PMC2887983.


Rao P, Berthier C, Nair V, Eichinger F, Henger A, Cohen C, Kretzler M. A transcriptomic approach for lupus nephritis classification. Am Jn Kid Dis 2008 51 4 A82


Bogan KL, Evans C, Belenky P, Song P, Burant CF, Kennedy R, Brenner C. Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside. J Biol Chem. 2009 Dec 11;284(50):34861-9. 888888: 19846558. PMCID: PMC2787348


Pierchala BA, Muñoz MR, Tsui CC. Proteomic analysis of the slit diaphragm complex: CLIC5 is a protein critical for podocyte morphology and function. Kidney Int. 2010 Nov;78(9):868-82. Epub 2010 Jul 21.


Fukuda A, Chowdhury M, Venkatareddy M, Wang SQ, Nishizono R, Wickman L, Wiggins J, Muchayi T, Fingar D, Shedden K, Inoki K and Wiggins RC. Growth-dependent podocyte failure causes glomerulosclerosis. J Am Soc Nephrol. E-pub 2012. PMCID: PMC3402293

Fukuda A, Wickman L, Venkatareddy M, Wang SQ, Chowdhury M, Wiggins J, Shedden K, Wiggins RC. Urine podocin:nephrin mRNA ratio as a podocyte stress biomarker. Nephrology, Dialysis and Transplantation. 2012. ePub ahead of print. 888888: 22863839.

Fukuda A, Wickman LT, Venkatareddy M, Sato Y, Chowdhury M, Wang SQ, Shedden K, Dysko R, Wiggins J and Wiggins RC. Angiotensin II-dependent persistent podocyte loss from destabilized glomeruli causes progression of end stage kidney disease. Kidney Int. 81:40-55, 2011. 888888: 21937979.

Heeringa S, Chernin G, Chaki M, Zhou W, Sloan A, Ji Z, Letian X, Salviati L, Hurd T, Vega-Warner V, Killen P, Raphael Y, Ashraf S, Ovunc B, Schoeb D, McLaughlin H, Airik R, Vlangos C, Gbadegesin R, Hinkes B, Saisawat1 P, Trevisson P, Doimo M, Casarin A, Pertegato V, Giorgi G, Prokisch H, Rötig A, Corinne Antignac C, Nurnberg G, Becker C, Wang S, Ozaltin F, Topaloglu R, Bakkaloglu A, Bakkaloglu S, Müller d, Beissert A, Mir S, Berdeli A, Özen S, Zenker M, Matejas V, Ocana C, Navas P, Kusakabe T, Kispert A, Soliman N, Krick S, Mundel P, Reiser J, Nurnberg P, Clarke C, Wiggins RC, Faul C, Hildebrandt F. COQ6 mutations cause nephrotic syndrome with sensorineural deafness in parallel with increased apoptosis J Clin Invest. 121:2013-2024, 2011 PMCID: PMC3083770

Sato Y, Wharram B, S Lee SK, Wickman L, Goyal M, Venkatareddy M, Chang JW, Wiggins J, Lienczewski C, Kretzler M and Wiggins RC. Urine podocyte mRNAs mark progression of renal disease. J Am Soc Nephrol. 20:1041-52, 2009. PMCID: PMC2678045

Wiggins JE, Patel SR, Shedden KA, Goyal M, Wharram BL, Martini S, Kretzler M, Wiggins RC. NF-kappaB promotes inflammation, coagulation, and fibrosis in the aging glomerulus. J Am Soc Nephrol. 2010 Apr.; 21(4):587-97. PMCID: PMC2844310


Zhou W*, Hildebrandt F. Inducible Podocyte Injury and Proteinuria in Transgenic Zebrafish. J Am Soc Nephrol. 2012 Jun;23(6):1039-47 (*Corresponding author), EM core was used for the above publications.PMCID: PMC3358760

Zhou W, Boucher RC, Bollig F, Englert C, Hildebrandt F. Characterization of mesonephric development and regeneration using transgenic zebrafish. Am J Physiol Renal Physiol. 299(5):F1040-7, 2010. 888888: 20810610. PMCID: PMC2980409