Kidney Educational Enrichment Program

KEEP Seminar
    • The Kidney Educational Enrichment Program (KEEP) program will focus on a broad range of opportunities to excite and involve students and residents as well as new investigators in kidney disease research and will, at the same time, promote new interactions and opportunities between established investigators. KEEP will particularly focus on teaching and training in relation to Applied Systems Biology and promoting translational interactions between basic and clinical scientists. 

Program Committee 

This committee will oversee all aspects of the KEEP program. The main focus will be to evaluate efficacy of components of the KEEP program, especially those where Center resources are being used. 

  • Chip Brosius
  • Crystal Gadegbeku
  • Ben Margolis
  • David Kershaw
  • Sub Pennathur
  • Roger Wiggins

Seminars

2016 - 2018

  • October 2, 2018

Dr. Greg Dressler will present "Pax genes and epigenetic regulation in kidney development and disease

  • September 25, 2018
  • Dr. James Morrissey will present “Polyphosphate: An Ancient Molecule with New Roles in Hemostasis, Thrombosis & Inflammation” 
  • September 11, 2018 NEW LOCATION! M5330 Med Sci I
  • Dr. Deepak Nagrath will present "Targeting Tumor & Microenvironment Using Metabolic Systems Biology"
  • June 19, 2018
  • Dr. Ilka Decker will present "The Endothelial Cell Transcriptome in Fabry Disease" and Dr. Doug Atchison will present "The Role of Phospholipase Ce1 in the Development of Proteinuria"
  • June 12, 2018
  • Dr. Jason Watts will present "Cis- and Trans-acting Determinants of RNA Polymerase Pausing in Human Cells"
  • June 5, 2018
  • Dr. Matt Sampson will present "A GWAS of Pediatric SSNS & Kidney Compartment Specific eQTL Maps"
  • May 22, 2018
  • Dr. Lois Weisman will present "From yeast to humans: Insights into phosphoinositide lipid signaling"
  • May 15, 2018
  • Dr. Jeffrey Beamish will present "Renal Epithelial Differentiation in Engineered Microvascular Niches"
  • May 8, 2018
  • Faculty candidate Dr. Markus Rinschen will present “Muti-Layered Proteomic Analysis of Podocyte Injury” 
  • May 1, 2018
  • Dr. Jacob Kitzman will present "Massively Parallel Approaches to Tackle Variants of Uncertain Significance"
  • April 24, 2018
  • Dr. Richard Mortensen: "“TCA cycle derivatives controlling ischemia/reperfusion and inflammation: Focus on itaconate” 
  • April 17, 2018
  • Dr. Puneet Garg: "Nephrin: Can I have some more?"
  • April 10, 2018
  • Dr. Ryan Mills - "Excavating the Deep Genome: Deciphering Structural Variation in Complex & Repetitive Regions"
  • April 3, 2018
  • Dr. Shigeki Iwase - "Impact of the Complex Brain Transcriptome on Chromatin and Synapses"
  • March 27, 2018
  • Dr. Joel Weinberg - "Searching for the Holy Grail - The Membrane Target for Glycine Cytoprotection"
  • March 20, 2018
  • Dr. Evan Farkash - "Late Renal Allograft Outcomes: ABMR, NK Cells, and Viral Oncogenesis"
  • March 13, 2018
  • Dr. Jorge Iniguez-Lluhi - "Nuclear Receptor Regulation Through SUO Modification: Impact on Human Disease"
  • March 7, 2018
  • Dr. Anna Mathew 'Cardiovascular Disease Risk & Dysfunctional High Density Lipoprotein"
  • February 26, 2018
  • No Basic Science Seminar
  • February 13, 2018
    Jun Li, PhD - "Single-cell genomics: Hitchhiking the Inner Galaxies"
  • February 6, 2018
    Michael Boehnke, PhD - "Identifying Genes for Type 2 Diabetes & Related Traits Using Genetic Association Studies"
  • January 30, 2018
    James Shayman, MD - "Son of Eliglustat"
  • January 23, 2018
    Maggie Chen, MD, PhD - "Endoplasmic Reticulum Stress & Genetic Mutations in Precision Nephrology"
  • January 16, 2018
    Roger Wiggins, MB, BChir - "Modeling Podocyte Hypertrophic Stress and its Consequences"
  • December 19, 2017
    Peter Arvan, MD, PhD - "Physiology & Disease in the Thyroid Epithelium"
  • December 12, 2017
    Anthony Antonellis, MD - Genetic and genomic approaches for studying peripheral nerve development & related human diseases"
  • November 28, 2017
    Jonathan M. Shillingford, PhD - "Interrogating Signaling Pathways in Polycystic Kidney Disease (PKD)"
  • November 21, 2017
    Dan Beard, PhD - "Multi-scale modeling and simulation in physiology: Examples from cardiac mechanics, metabolism, and whole-body cardiovascular dynamics"
  • November 14, 2017
    Charles Burant, MD - "High oxidative capacity, mechanisms underlying a long, healthy life!"
  • October 24, 2017
    Jennifer Schaub, MD - "Because It's There: Untangling Human AKI"
  • October 17, 2017
    Matthew Delano, MD - "Acute Kidney Injury is Complement Dependent in Diet Induced Obesity Following Trauma and Sepsis"
  • October 10, 2017
    Vivian Cheung, MD - "Why nucleic acid structure matters: Lessons from a motor neuron disorder"
  • October 3, 2017
    Daniel Goldstein, MD - "Novel Pathways of Aging + Inflammation"
  • September 26, 2017
    Michelle Kahlenberg, MD, PhD - "Lupus: Is there a skin/kidney connection?"
  • September 19, 2017
    Jun He Lee, PhD - "Systematic Characterization of Stress Granule Transcriptome"
  • June 27, 2017
    Eugene Rhee, MD - "Lipidomics: Biomarkers to Biology?"
  • June 20, 2017
    Jeff Hodgin, MD, PhD - "Caspase-1 and the Inflammasome in Glomerular Injury"
  • June 13,2017
    Toralf Melsom, PhD - "Hyperfiltration, Albuminuria & Rapid GFR decline in the General Non-Diabetic Population"
  • June 6, 2017
    Weibin Zhou, PhD - "What Can We Learn From Zebrafish Podocytes?"
  • May 30,2017
    Puneet Garg, MD - "Does Nephrin Have a Role in a Mature Slit Diaphragm?"
  • May 23, 2017
    Anna Mathew, MD – “Role of Myeloperoxidase in Chronic Kidney Disease Accelerated Atherosclerosis"
  • May 16, 2017
    Jennifer Harder, MD – “Modeling Diabetic Kidney Disease with Kidney Organoids"
  • May 9, 2017
    Jennie Lin, MD, University of Pennsylvania – “From Genome to Novel Biology:  Functional Genomics in Cardiometabolic & Renal Diseases”
  • May 2, 2017
    Cristina Cebrian Ligero, MD – “Single cell transcriptional profiling of the developing human kidney"
  • April 18, 2017
    Edgar Otto, PhD – “Droplet-based single cell transcriptomic in Kidney Research”
  • April 11, 2017
    Ken Inoki, MD, PhD - "Regulation of Rheb Small GTPase in Cell Growth Control"
  • April 4, 2017
    Jeff Beamish, MD - "Engineered Extracellulr Matrices with Controlled Mechanics Modulate Renal Cell Proximal Tubular Cell Epithelialization"
  • March 28, 2017
    Matt Sampson, MD – “Empowering GWAS through a Nephrotic Syndrome Severity Score”
  • March 21, 2017
    Roger Wiggins, MD – “Podometrics as a Clinical Tool for Progression Management & Prevention"
  • March 14, 2017
    Vania Hinkovska-Galcheva, PhD - "Structural & Functional Analysis of 1-0 AcylceramideSynthase (Lysosomal Phospholipase A2): A Work in Progress"       
  • March 7, 2017 
    Raymond Yung, MD - "Obesity, Inflammation & Aging"   
  • February 28, 2017          
    Jeanie Park, MD - "Sypathetic Regulation During Physical Activity in Chronic Kidney Disease", Emory University
  • February 21, 2017        
    Yatrik Shah, PhD - "Hypoxia & Iron Metabolism: Fueling the Fire for Colon Cancer"
  • February 14, 2017          
    Alan Smrcka, PhD - "Regulation of Phospholipase C Epsilon (PLCE1) in the Heart"
  • January 31, 2017            
    Richard Miller, PhD - "Cool Stuff you can do with Slow-Aging Mice"
  • January 24, 2017
    James Shayman, MD - "New Insights into the structure and function of lysosomal phospholipase A2"
  • January 10, 2017            
    Sundararaman Swaminathan, MD - "Targeting Iron Homeostasis for Inducing Protection in Acute Kidney Injury"
  • December 13, 2016        
    Martin Myers, MD, PhD - “Molecular & Neural Mechanisms of Leptin Action”
  • December 6, 2016     
    Chip Brosius, MD - "Inflammation in Diabetic Kidney Disease: New Targets for Therapy"
  • November 29, 2016
    Kevin Atkins, PhD - "Altered Vascular Smooth Muscle GLUT4 Expression: Effect on Vascular Function in Diabetes and Beyond"
  • November 22, 2016
    Krishnan Raghavendran, MD - "Toll-like receptor 3 in lung injury"
  • November 8, 2016         
    Mats Ljungman, PhD - "Using nascent RNA Bru-seq to profile cellular responses to stress and re-programming"
  • November 2, 2016
    Steven Huang, MD - "Epigenetic Changes in Lung Fibroblasts: Insights into Novel Fibrogenic Pathways"
  • October 25, 2016
    Nick Lukacs, PhD - "Microbiome Alteration of Immune Responses and Targeting Pulmonary Disease"
  • October 18, 2016
    Eugene Chen, MD – “Advancing Lipid Gene Discoveries to Innovative Targets for Cardiovascular Disease”
  •  October 11, 2016            
    Lonnie Shea, PhD - "Regenerative Medicine: Preventing Tissue Degeneration & Promoting Regrowth"
  • October 4, 2016
    Shuichi Takayama, PhD - "Microfluidics & Organs on a Chip"
  • September 20, 2016      
    Bethany Moore, PhD - "Regulation of Pulmonary Fibrosis by Periostin"
  • September 13, 2016     
     Julie D. Saba, MD, PhD - "Mutations in Sgpl1 as a cause of focal segmentalglomerulosclerosis (FSGS)"
  • September 9, 2017
    Vincent Young, MD, PhD - "Microbial and Metabolic Aspects of C.difficile Infection in the Gut"

2015 - 2016

  • May 24, 2016
    Matthew Sampson, MD, MSCE - "The Genetic Determinants of Nephrotic Syndrome in Ann Arbor"
  • May 17, 2016
    Markus Bitzer, MD - "New Insights into 'Imploding' Glomerulopathy"
  • May 10, 2016
    Weibin Zhou, PhD - "Zebrafish Model of Nephrotic Syndrome"
  • May 3, 2016
    Roy Zent, M.D. - "Integrins in the Kidney"
  • April 12, 2016
    Greg Dressler, PhD. - "Developing Novel Small Molecules for Treating Renal Disease"
  • April 5, 2016
    Sanjeevkumar Patel, M.D. - "Pax2, Vasopressin Receptor and Lithium Nephrotoxicity: Is there a Link?"
  • March 29, 2016
    Evan A. Farkash, M.D., Ph.D. - "Make Antibody Mediated Rejection Diagnosis Great Again!"
  • March 22, 2016
    Joel M. Weinberg, M.D. - "New Insights Into Tubule Cell Injury and Death During Acute Kidney Injury"
  • March 15, 2016
    Maryam Afkarian, M.D., Ph.D. - "Using Omics to Understand Human Diabetic Kidney Disease"
  • December 8, 2015
    Jun Wu, Ph.D. - "Molecular Regulation and Therapeutic Potential of Brown and Beige Fat"
  • December 1, 2015
    Peter K. Henke, M.D. - "Experimental insights into post thrombotic syndrome"
  • November 24, 2015
    Jeffrey L. Platt, M.D. - "An Odd Tubular Cell: origin and implications"
  • November 10, 2015
    Stefan W. Stoll, Ph.D. - "The Membrane-Tethered Intracellular Domain of Amphiregulin Promotes Keratinocyte Proliferation"
  • October 27, 2015
    Paul Jenkins, Ph.D. - "Ankyrin and Spectrin: Critical Players in the Formation of Polarized Epithelia"
  • October 13, 2015
    Andrew J. Putnam, Ph.D. - "Microenvironmental Control of Cell Fate for Regenerative Applications"
  • October 6, 2015
    Roberto I. Vazquez-Padron, Ph.D., FAHA - "Understanding Arteriovenous Fistula Failure: What Have We Learned So Far?"
  • September 29, 2015
    Akira Ono, Ph.D. - "Driving HIV-1 Gag to the Virus Assembly Sites: Lipids and RNA are in Charge"
  • September 22, 2015
    Jason S. Knight, M.D., Ph.D. - "Neutrophils in the Antiphospholipid Syndrome: NET Gain in Understanding APS Pathogenesis?"

2014 - 2015

  • May 19, 2015
    - Subramaniam Pennathur, MBBS - "Tissue-Specific Metablolic Reprogramming Drives Enhanced Nutrient Flux in Diabetic Kidney Disease"
  • May 12, 2015
    - Zheng Dong, Ph.D. - "Mitochondrial Dynamics in Cell Death: A Tale of Two Membranes"
  • May 5, 2015
    - Cristina Cebrian, Ph.D. - "New in vivo and in vitro Models to Study Polycystic Kidney Disease"
  • April 21, 2015
    - Sangeevkumar R. Patel, M.D. - "An Update on the Roleof Pax2 and PTIP in Transcriptional Regulation"
  • April 14, 2015
    - Puneet Garg, M.D. - "Podocytes Have Low Levels of Basal Endocytic Flux"
  • March 31, 2015
    - Greg Dressler, Ph.D. - "Shifting the TGF-b/BMP Signaling Paradigm in Renal and Metabolic Disease"
  • March 24, 2015
    - Weibin Zhou, Ph.D. - "The Role of Caveolin-1 in Podocyte Injury"
  • March 17, 2015
    - Ken Inoki, M.D., Ph.D. - "Role of Ragulator in Podocytes
  • March 10, 2015
    - Tom Tuschl, Ph.D. - "RNA Regulation & RNA Diagnostics"
  • March 3, 2015
    - Edgar Otto, Ph.D. - "Pitfalls and Challenges in Autosomal Dominant Kidney Disease Gene Identification"
  • February 24, 2015
    - Randy J. Seeley, Ph.D. - "Bariatric Surgery: It's not what you think it is. Molecular mechanisms for the effects of surgery on obesity and diabetes"
  • February 17, 2015
    - Markus Bitzer, M.D. - "MicroRNA-Mediated Mechanism in Podoctye Injury"
  • February 10, 2015
    - Roger Wiggins, MB, BChir - "Progression as a Zero-Sum Game"
  • February 3, 2015
    - Bing Ye, Ph.D. - "The Regulation of the Golgi in Neuronal Polarity"
  • January 20, 2015
    - Jianping Fu, Ph.D. - "Hippo/YAP-Mediated Rigidity-Dependent Motor Neuron Differentiation of Human Pluripotent Stem Cells"
  • December 9, 2014
    - Ernestina Schipani, M.D., Ph.D. - "Hypoxia, HIFs and VHL in Development and Disease"
  • December 2, 2014
    - Henry Paulson, M.D., Ph.D. - "Ubiquitin Pathways in Neurodegenerative Disease"
  • November 25, 2014
    - Ormond A. MacDougald, Ph.D. - "Endocrine and Metabolic Functions of Marrow Adipose Tissue"
  • November 18, 2014
    - David B. Lombard, M.D., Ph.D. - "SIRT5 as a Novel Therapeutic Target in Cancer"
  • November 4, 2014
    - Arash Scott Soleimanpour M.D. - "Out with the old, in with the new...Mitophagy as a novel regulator of pancreatic beta cell function"
  • October 28, 2014
    - Gary D. Luker, M.D. - "Chemokine CXCL12: Multiple Isoforms and Effects"
  • October 14, 2014
    - Alisa Glukhova, M.D. - "Structure and Function of Lysosomal Phospholipase A2 and Lecithin: Cholesterol Acyltransferase"
  • October 7, 2014
    - Yatrik Shah, Ph.D. - "Intestinal Oxygen Dynamics in Systemic Iron Homeostasis"
  • September 30, 2014
    - Jordan Adam Shavit, M.D. - "Modeling Disorders of Hemostatis and Thrombosis Through Genome Editing in Zebrafish"
  • September 23, 2014
    - Cristen J. Willer, Ph.D. - "Understanding the Genetic Basis of Cardiovascular Disease and Related Risk Factors"
  • June 12, 2014
    - Andrey S. Shaw, M.D. - "THe Role of CD2AP in Podocyte Injury and Repair"