The primary goal of the C-PROBE is to develop an infrastructure that will serve as an interface between patients in the clinical care settings and biomedical investigators conducting translational research in kidney disease.
The C-PROBE objectives are as follows:
- To establish a collaborative agreement for operating a biomedical research core among five institutions:
- St. Clair Nephrology Research
- The University of Michigan Nephrology Program
- The Wayne State University School of Medicine Nephrology Program
- Temple University, Philadelphia
- Levine Children's Hospital
- To establish an ethnically diverse pool of human research subjects consisting of individuals with kidney disease.
- To develop a streamlined infrastructure for recruitment of human subjects into clinical and translational research protocols using a customized, secure, web-based relational clinical research data management system.
- To maintain a centralized bank of biological specimens and clinical data.
Information/Samples collected on each subject include:
- Urine Supernatant – 14.4 mL (Maximum distributed for any research study is 2.5 mL)
- Urine Pellet (re-suspended in RNAlater) – 0.2 mL
- Blood Plasma – 14.4 mL (Maximum distributed for any research study is 1.0 mL)
- Blood Serum – 9.6 mL (Maximum distributed for any research study is 1.0 mL)
- RNA Paxgene tube (1)
- DNA – DNA Paxgene tube (1) or DNA processed with Gentra system