Chronic Kidney Disease and Related Long-Term Complications After Liver Transplantation.

Publication Type:

Journal Article

Source:

Adv Chronic Kidney Dis, Volume 22, Issue 5, p.404-11 (2015)

Keywords:

Disease Progression, End Stage Liver Disease, Female, Graft Rejection, Graft Survival, Humans, Kidney Failure, Chronic, Liver Transplantation, Male, Prognosis, Risk Assessment, Survival Analysis, Treatment Outcome

Abstract:

Liver transplantation is the standard of care for patients with decompensated cirrhosis. Liver transplantation recipients have excellent short-term and long-term outcomes including patient and graft survival. Since the adoption of model for end-stage liver disease (MELD)-based allocation policy, the incidence of post-transplant end stage renal disease has risen significantly. Occurrence of Stage 4 chronic kidney disease and end stage renal disease substantially increases the risk of post-transplant deaths. Because majority of late post-transplant mortality is due to nonhepatic post-transplant comorbidities, personalized care directed toward risk factor modification may further improve post-transplant survival.