C-PROBE Core

Submit Ancillary Proposal
The primary goal of the C-PROBE is to develop an infrastructure that will serve as an interface between patients in the clinical care settings and biomedical investigators conducting translational research in kidney disease.

The C-PROBE objectives are as follows:

  1. To establish a collaborative agreement for operating a biomedical research core among five institutions:
    • University of Illinois, Chicago
    • Renaissance Renal Research Institute
    • The University of Michigan Nephrology Program
    • The Wayne State University School of Medicine Nephrology Program
    • Temple University, Philadelphia
  2. To establish an ethnically diverse pool of human research subjects consisting of individuals with kidney disease.
  3. To develop a streamlined infrastructure for recruitment of human subjects into clinical and translational research protocols using a customized, secure, web-based relational clinical research data management system.
  4. To maintain a centralized bank of biological specimens and clinical data.

Information/Samples collected on each subject include:

Phenotypic Data:

Biological Specimens:

  • Urine Supernatant – 14.4 mL (Maximum distributed for any ancillary study is 2.5 mL)
  • Urine Pellet (re-suspended in RNAlater) – 0.2 mL
  • Blood Plasma – 14.4 mL
  • RNA Paxgene tube (1)
  • DNA – DNA Paxgene tube (1) or DNA processed with Gentra system

Description of Currently Enrolled C-PROBE Subjects